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8FXS

Crystal structure of human pro-TGF-beta2 in complex with Nb9

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001501biological_processskeletal system development
A0001502biological_processcartilage condensation
A0001540molecular_functionamyloid-beta binding
A0001568biological_processblood vessel development
A0001654biological_processeye development
A0001666biological_processresponse to hypoxia
A0001822biological_processkidney development
A0001837biological_processepithelial to mesenchymal transition
A0001843biological_processneural tube closure
A0001942biological_processhair follicle development
A0001974biological_processblood vessel remodeling
A0003007biological_processheart morphogenesis
A0003148biological_processoutflow tract septum morphogenesis
A0003149biological_processmembranous septum morphogenesis
A0003151biological_processoutflow tract morphogenesis
A0003179biological_processheart valve morphogenesis
A0003181biological_processatrioventricular valve morphogenesis
A0003184biological_processpulmonary valve morphogenesis
A0003203biological_processendocardial cushion morphogenesis
A0003215biological_processcardiac right ventricle morphogenesis
A0003222biological_processventricular trabecula myocardium morphogenesis
A0003274biological_processendocardial cushion fusion
A0003289biological_processatrial septum primum morphogenesis
A0003407biological_processneural retina development
A0005102molecular_functionsignaling receptor binding
A0005114molecular_functiontype II transforming growth factor beta receptor binding
A0005125molecular_functioncytokine activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005768cellular_componentendosome
A0006924biological_processactivation-induced cell death of T cells
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007411biological_processaxon guidance
A0007423biological_processsensory organ development
A0007435biological_processsalivary gland morphogenesis
A0007507biological_processheart development
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008347biological_processglial cell migration
A0008584biological_processmale gonad development
A0009611biological_processresponse to wounding
A0009792biological_processembryo development ending in birth or egg hatching
A0010002biological_processcardioblast differentiation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010634biological_processpositive regulation of epithelial cell migration
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010936biological_processnegative regulation of macrophage cytokine production
A0014706biological_processstriated muscle tissue development
A0016477biological_processcell migration
A0016525biological_processnegative regulation of angiogenesis
A0023052biological_processsignaling
A0030097biological_processhemopoiesis
A0030198biological_processextracellular matrix organization
A0030199biological_processcollagen fibril organization
A0030307biological_processpositive regulation of cell growth
A0030308biological_processnegative regulation of cell growth
A0030326biological_processembryonic limb morphogenesis
A0030424cellular_componentaxon
A0030593biological_processneutrophil chemotaxis
A0030855biological_processepithelial cell differentiation
A0031012cellular_componentextracellular matrix
A0031069biological_processhair follicle morphogenesis
A0031093cellular_componentplatelet alpha granule lumen
A0032570biological_processresponse to progesterone
A0032874biological_processpositive regulation of stress-activated MAPK cascade
A0032909biological_processregulation of transforming growth factor beta2 production
A0032956biological_processregulation of actin cytoskeleton organization
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0034714molecular_functiontype III transforming growth factor beta receptor binding
A0035910biological_processascending aorta morphogenesis
A0042060biological_processwound healing
A0042127biological_processregulation of cell population proliferation
A0042416biological_processdopamine biosynthetic process
A0042476biological_processodontogenesis
A0042704biological_processuterine wall breakdown
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0045216biological_processcell-cell junction organization
A0045597biological_processpositive regulation of cell differentiation
A0045726biological_processpositive regulation of integrin biosynthetic process
A0045747biological_processpositive regulation of Notch signaling pathway
A0045787biological_processpositive regulation of cell cycle
A0045823biological_processpositive regulation of heart contraction
A0046580biological_processnegative regulation of Ras protein signal transduction
A0048103biological_processsomatic stem cell division
A0048566biological_processembryonic digestive tract development
A0048663biological_processneuron fate commitment
A0048666biological_processneuron development
A0048699biological_processgeneration of neurons
A0048839biological_processinner ear development
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050714biological_processpositive regulation of protein secretion
A0050778biological_processpositive regulation of immune response
A0051130biological_processpositive regulation of cellular component organization
A0051240biological_processpositive regulation of multicellular organismal process
A0051781biological_processpositive regulation of cell division
A0051794biological_processregulation of timing of catagen
A0051795biological_processpositive regulation of timing of catagen
A0051891biological_processpositive regulation of cardioblast differentiation
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060038biological_processcardiac muscle cell proliferation
A0060065biological_processuterus development
A0060317biological_processcardiac epithelial to mesenchymal transition
A0060325biological_processface morphogenesis
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0060412biological_processventricular septum morphogenesis
A0060413biological_processatrial septum morphogenesis
A0061037biological_processnegative regulation of cartilage development
A0061626biological_processpharyngeal arch artery morphogenesis
A0062009biological_processsecondary palate development
A0062043biological_processpositive regulation of cardiac epithelial to mesenchymal transition
A0070237biological_processpositive regulation of activation-induced cell death of T cells
A0071363biological_processcellular response to growth factor stimulus
A0090091biological_processpositive regulation of extracellular matrix disassembly
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
A1900182biological_processpositive regulation of protein localization to nucleus
A1902256biological_processregulation of apoptotic process involved in outflow tract morphogenesis
A1902895biological_processpositive regulation of miRNA transcription
A1903053biological_processregulation of extracellular matrix organization
A1903659biological_processregulation of complement-dependent cytotoxicity
A1903701biological_processsubstantia propria of cornea development
A1904238biological_processpericyte cell differentiation
A1904888biological_processcranial skeletal system development
A1905006biological_processnegative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
A1905007biological_processpositive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000902biological_processcell morphogenesis
B0001501biological_processskeletal system development
B0001502biological_processcartilage condensation
B0001540molecular_functionamyloid-beta binding
B0001568biological_processblood vessel development
B0001654biological_processeye development
B0001666biological_processresponse to hypoxia
B0001822biological_processkidney development
B0001837biological_processepithelial to mesenchymal transition
B0001843biological_processneural tube closure
B0001942biological_processhair follicle development
B0001974biological_processblood vessel remodeling
B0003007biological_processheart morphogenesis
B0003148biological_processoutflow tract septum morphogenesis
B0003149biological_processmembranous septum morphogenesis
B0003151biological_processoutflow tract morphogenesis
B0003179biological_processheart valve morphogenesis
B0003181biological_processatrioventricular valve morphogenesis
B0003184biological_processpulmonary valve morphogenesis
B0003203biological_processendocardial cushion morphogenesis
B0003215biological_processcardiac right ventricle morphogenesis
B0003222biological_processventricular trabecula myocardium morphogenesis
B0003274biological_processendocardial cushion fusion
B0003289biological_processatrial septum primum morphogenesis
B0003407biological_processneural retina development
B0005102molecular_functionsignaling receptor binding
B0005114molecular_functiontype II transforming growth factor beta receptor binding
B0005125molecular_functioncytokine activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005768cellular_componentendosome
B0006924biological_processactivation-induced cell death of T cells
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007411biological_processaxon guidance
B0007423biological_processsensory organ development
B0007435biological_processsalivary gland morphogenesis
B0007507biological_processheart development
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0008347biological_processglial cell migration
B0008584biological_processmale gonad development
B0009611biological_processresponse to wounding
B0009792biological_processembryo development ending in birth or egg hatching
B0010002biological_processcardioblast differentiation
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010634biological_processpositive regulation of epithelial cell migration
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010936biological_processnegative regulation of macrophage cytokine production
B0014706biological_processstriated muscle tissue development
B0016477biological_processcell migration
B0016525biological_processnegative regulation of angiogenesis
B0023052biological_processsignaling
B0030097biological_processhemopoiesis
B0030198biological_processextracellular matrix organization
B0030199biological_processcollagen fibril organization
B0030307biological_processpositive regulation of cell growth
B0030308biological_processnegative regulation of cell growth
B0030326biological_processembryonic limb morphogenesis
B0030424cellular_componentaxon
B0030593biological_processneutrophil chemotaxis
B0030855biological_processepithelial cell differentiation
B0031012cellular_componentextracellular matrix
B0031069biological_processhair follicle morphogenesis
B0031093cellular_componentplatelet alpha granule lumen
B0032570biological_processresponse to progesterone
B0032874biological_processpositive regulation of stress-activated MAPK cascade
B0032909biological_processregulation of transforming growth factor beta2 production
B0032956biological_processregulation of actin cytoskeleton organization
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0034714molecular_functiontype III transforming growth factor beta receptor binding
B0035910biological_processascending aorta morphogenesis
B0042060biological_processwound healing
B0042127biological_processregulation of cell population proliferation
B0042416biological_processdopamine biosynthetic process
B0042476biological_processodontogenesis
B0042704biological_processuterine wall breakdown
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0045216biological_processcell-cell junction organization
B0045597biological_processpositive regulation of cell differentiation
B0045726biological_processpositive regulation of integrin biosynthetic process
B0045747biological_processpositive regulation of Notch signaling pathway
B0045787biological_processpositive regulation of cell cycle
B0045823biological_processpositive regulation of heart contraction
B0046580biological_processnegative regulation of Ras protein signal transduction
B0048103biological_processsomatic stem cell division
B0048566biological_processembryonic digestive tract development
B0048663biological_processneuron fate commitment
B0048666biological_processneuron development
B0048699biological_processgeneration of neurons
B0048839biological_processinner ear development
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050714biological_processpositive regulation of protein secretion
B0050778biological_processpositive regulation of immune response
B0051130biological_processpositive regulation of cellular component organization
B0051240biological_processpositive regulation of multicellular organismal process
B0051781biological_processpositive regulation of cell division
B0051794biological_processregulation of timing of catagen
B0051795biological_processpositive regulation of timing of catagen
B0051891biological_processpositive regulation of cardioblast differentiation
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060038biological_processcardiac muscle cell proliferation
B0060065biological_processuterus development
B0060317biological_processcardiac epithelial to mesenchymal transition
B0060325biological_processface morphogenesis
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0060412biological_processventricular septum morphogenesis
B0060413biological_processatrial septum morphogenesis
B0061037biological_processnegative regulation of cartilage development
B0061626biological_processpharyngeal arch artery morphogenesis
B0062009biological_processsecondary palate development
B0062043biological_processpositive regulation of cardiac epithelial to mesenchymal transition
B0070237biological_processpositive regulation of activation-induced cell death of T cells
B0071363biological_processcellular response to growth factor stimulus
B0090091biological_processpositive regulation of extracellular matrix disassembly
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
B1900182biological_processpositive regulation of protein localization to nucleus
B1902256biological_processregulation of apoptotic process involved in outflow tract morphogenesis
B1902895biological_processpositive regulation of miRNA transcription
B1903053biological_processregulation of extracellular matrix organization
B1903659biological_processregulation of complement-dependent cytotoxicity
B1903701biological_processsubstantia propria of cornea development
B1904238biological_processpericyte cell differentiation
B1904888biological_processcranial skeletal system development
B1905006biological_processnegative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
B1905007biological_processpositive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYnanfCaGaC
ChainResidueDetails
AILE331-CYS346

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN72
AARG140
AASN241
BASN72
BARG140
BASN241

237992

PDB entries from 2025-06-25

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