8FXS
Crystal structure of human pro-TGF-beta2 in complex with Nb9
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transforming growth factor beta-2 proprotein | polymer | 393 | 45195.4 | 2 | UniProt (P61812) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (human) | Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF |
| 2 | C, D (D, E) | Nanobody clone 9 | polymer | 124 | 13802.2 | 2 | synthetic construct | ||
| 3 | E, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | G, H, I (A, B, E) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 410 (UniProt: P61812)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
| Pro 19 | - | expression tag |
| Ser 20 | - | expression tag |
| Ser 24 | Cys 24 | engineered mutation |
| Arg 140 | Asn 140 | engineered mutation |
| Gly 298 | Arg 298 | engineered mutation |
| - | Arg 299 | deletion |
| - | Lys 300 | deletion |
| - | Lys 301 | deletion |
| - | Arg 302 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117995.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 118437.7 |
