4FAO

Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Summary for 4FAO

DescriptorGrowth/differentiation factor 2, Serine/threonine-protein kinase receptor R3, Activin receptor type-2B, ... (5 entities in total)
Functional Keywordstgf-beta, ctk, cystine knot, extracellular domain, receptor, signaling protein-signaling protein complex, signaling protein/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted Q9UK05
Membrane; Single-pass type I membrane protein P37023
Cell membrane; Single-pass type I membrane protein (By similarity) Q13705
Total number of polymer chains36
Total molecular weight459216.2
Authors
Townson, S.A.,Martinez-Hackert, E.,Greppi, C.,Lowden, P.,Sako, D.,Liu, J.,Ucran, J.A.,Liharska, K.,Underwood, K.W.,Seehra, J.,Kumar, R.,Grinberg, A.V. (deposition date: 2012-05-22, release date: 2012-06-20, Last modification date: 2012-08-29)
Primary citation
Townson, S.A.,Martinez-Hackert, E.,Greppi, C.,Lowden, P.,Sako, D.,Liu, J.,Ucran, J.A.,Liharska, K.,Underwood, K.W.,Seehra, J.,Kumar, R.,Grinberg, A.V.
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex.
J.Biol.Chem., 287:27313-27325, 2012
PubMed: 22718755 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.377960
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.357 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.251142.4%8.0%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution