4FAO

Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
E	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
E	0016020	cellular_component	membrane
F	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
F	0005524	molecular_function	ATP binding
F	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
F	0016020	cellular_component	membrane
G	0005576	cellular_component	extracellular region
G	0008083	molecular_function	growth factor activity
H	0005576	cellular_component	extracellular region
H	0008083	molecular_function	growth factor activity
K	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
K	0005524	molecular_function	ATP binding
K	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
K	0016020	cellular_component	membrane
L	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
L	0005524	molecular_function	ATP binding
L	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
L	0016020	cellular_component	membrane
M	0005576	cellular_component	extracellular region
M	0008083	molecular_function	growth factor activity
N	0005576	cellular_component	extracellular region
N	0008083	molecular_function	growth factor activity
Q	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
Q	0005524	molecular_function	ATP binding
Q	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
Q	0016020	cellular_component	membrane
R	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
R	0005524	molecular_function	ATP binding
R	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
R	0016020	cellular_component	membrane
S	0005576	cellular_component	extracellular region
S	0008083	molecular_function	growth factor activity
T	0005576	cellular_component	extracellular region
T	0008083	molecular_function	growth factor activity
W	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
W	0005524	molecular_function	ATP binding
W	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
W	0016020	cellular_component	membrane
X	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
X	0005524	molecular_function	ATP binding
X	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
X	0016020	cellular_component	membrane
a	0005576	cellular_component	extracellular region
a	0008083	molecular_function	growth factor activity
b	0005576	cellular_component	extracellular region
b	0008083	molecular_function	growth factor activity
e	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
e	0005524	molecular_function	ATP binding
e	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
e	0016020	cellular_component	membrane
f	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
f	0005524	molecular_function	ATP binding
f	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
f	0016020	cellular_component	membrane
g	0005576	cellular_component	extracellular region
g	0008083	molecular_function	growth factor activity
h	0005576	cellular_component	extracellular region
h	0008083	molecular_function	growth factor activity
k	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
k	0005524	molecular_function	ATP binding
k	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
k	0016020	cellular_component	membrane
l	0004675	molecular_function	transmembrane receptor protein serine/threonine kinase activity
l	0005524	molecular_function	ATP binding
l	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
l	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPkeYeayeCkGgC

Chain	Residue	Details
A	ILE26-CYS41

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	Region: {"description":"Interaction with ENG","evidences":[{"source":"PubMed","id":"28564608","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Mediates specificity for BMP ligand"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22718755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---