4FAO

Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, EA, FA, G... (A, B, G, H, M...)	Growth/differentiation factor 2	polymer	110	12103.0	12	UniProt (Q9UK05) Pfam (PF00019)	Homo sapiens (human)	GDF-2, Bone morphogenetic protein 9, BMP-9
2	AA, BA, C, D, GA... (C, D, I, J, O...)	Serine/threonine-protein kinase receptor R3	polymer	106	11592.9	12	UniProt (P37023)	Homo sapiens (human)	SKR3, Activin receptor-like kinase 1, ALK-1, TGF-B superfamily receptor type I, TSR-I
3	CA, DA, E, F, IA... (E, F, K, L, Q...)	Activin receptor type-2B	polymer	124	14118.3	12	UniProt (Q13705) Pfam (PF01064)	Homo sapiens (human)	Activin receptor type IIB, ACTR-IIB
4	AB, BB, CB, EB, FB... (W, X, e, f, k...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	24	Chemie (NAG)
5	DB, GB, LB, OA, RA... (X, e, k, F, K...)	SODIUM ION	non-polymer		23.0	6	Chemie (NA)

Sequence modifications

C, D, I, J, O, P, U, V, c, d, i, j: 22 - 118 (UniProt: P37023)

PDB	External Database	Details
Gly 20	-	expression tag
Ala 21	-	expression tag
Ser 119	-	expression tag
Gly 120	-	expression tag
Asp 121	-	expression tag
Asp 122	-	expression tag
Asp 123	-	expression tag
Asp 124	-	expression tag
Lys 125	-	expression tag

E, F, K, L, Q, R, W, X, e, f, k, l: 1 - 116 (UniProt: Q13705)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Gly 117	-	expression tag
Asp 118	-	expression tag
Asp 119	-	expression tag
Asp 120	-	expression tag
Asp 121	-	expression tag
Lys 122	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	36
	Total formula weight	453769.3
Non-Polymers*	Number of molecules	30
	Total formula weight	5446.9
All*	Total formula weight	459216.2

*Water molecules are not included.