8FXV
Crystal structure of human proTGF-beta2 in complex with Nb18
Summary for 8FXV
Entry DOI | 10.2210/pdb8fxv/pdb |
Related | 8FXS |
Descriptor | Transforming growth factor beta-2 proprotein, Nanobody clone 18, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | tgf-b tgf-beta nanobody latent procomplex prodomain, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 58936.44 |
Authors | |
Primary citation | Le, V.Q.,Zhao, B.,Ramesh, S.,Toohey, C.,DeCosta, A.,Mintseris, J.,Liu, X.,Gygi, S.,Springer, T.A. A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120:e2304874120-e2304874120, 2023 Cited by PubMed: 37279271DOI: 10.1073/pnas.2304874120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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