Author results

3PDS
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IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
Descriptor:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
Authors:Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
Deposit date:2010-10-24
Release date:2011-01-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
3VW7
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CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM
Descriptor:Proteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate, ...
Authors:Zhang, C., Srinivasan, Y., Arlow, D.H., Fung, J.J., Palmer, D., Zheng, Y., Green, H.F., Pandey, A., Dror, R.O., Shaw, D.E., Weis, W.I., Coughlin, S.R., Kobilka, B.K.
Deposit date:2012-08-07
Release date:2012-12-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High-resolution crystal structure of human protease-activated receptor 1
Nature, 492, 2012
4DAJ
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STRUCTURE OF THE M3 MUSCARINIC ACETYLCHOLINE RECEPTOR
Descriptor:Muscarinic acetylcholine receptor M3, Lysozyme, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, ...
Authors:Kruse, A.C., Hu, J., Pan, A.C., Arlow, D.H., Rosenbaum, D.M., Rosemond, E., Green, H.F., Liu, T., Chae, P.S., Dror, R.O., Shaw, D.E., Weis, W.I., Wess, J., Kobilka, B.
Deposit date:2012-01-12
Release date:2012-02-22
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Nature, 482, 2012
5C1M
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CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE AGONIST BU72
Descriptor:Mu-type opioid receptor, Nanobody 39, (2S,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, ...
Authors:Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K.
Deposit date:2015-06-15
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
5TVN
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CRYSTAL STRUCTURE OF THE LSD-BOUND 5-HT2B RECEPTOR
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ...
Authors:Wacker, D., Wang, S., McCorvy, J.D., Betz, R.M., Venkatakrishnan, A.J., Levit, A., Lansu, K., Schools, Z.L., Che, T., Nichols, D.E., Shoichet, B.K., Dror, R.O., Roth, B.L.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Cell, 168, 2017
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
5WIU
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STRUCTURE OF THE HUMAN D4 DOPAMINE RECEPTOR IN COMPLEX WITH NEMONAPRIDE
Descriptor:D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, ...
Authors:Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.
Deposit date:2017-07-20
Release date:2017-10-18
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
Science, 358, 2017
5WIV
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STRUCTURE OF THE SODIUM-BOUND HUMAN D4 DOPAMINE RECEPTOR IN COMPLEX WITH NEMONAPRIDE
Descriptor:D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, ...
Authors:Wacker, D., Wang, S., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Venkatakrishnan, A.J., Huang, X.-P., Dror, R.O., Shoichet, B.K., Roth, B.L.
Deposit date:2017-07-20
Release date:2017-10-18
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.143 Å)
Cite:D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
Science, 358, 2017
5X7D
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STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO CARAZOLOL AND AN INTRACELLULAR ALLOSTERIC ANTAGONIST
Descriptor:Chimera protein of Beta-2 adrenergic receptor and Lysozyme, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ...
Authors:Liu, X., Ahn, S., Kahsai, A.W., Meng, K.-C., Latorraca, N.R., Pani, B., Venkatakrishnan, A.J., Masoudi, A., Weis, W.I., Dror, R.O., Chen, X., Lefkowitz, R.J., Kobilka, B.K.
Deposit date:2017-02-25
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.
Nature, 548, 2017
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
6O3C
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CRYSTAL STRUCTURE OF ACTIVE SMOOTHENED BOUND TO SAG21K, CHOLESTEROL, AND NBSMO8
Descriptor:Smoothened homolog, NbSmo8, PHOSPHATE ION, ...
Authors:Deshpande, I.S., Liang, J., Hedeen, D., Roberts, K.J., Zhang, Y., Ha, B., Latorraca, N.R., Faust, B., Dror, R.O., Beachy, P.A., Myers, B.R., Manglik, A.
Deposit date:2019-02-26
Release date:2019-07-03
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.
Nature, 571, 2019
4XT1
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STRUCTURE OF A NANOBODY-BOUND VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1
Descriptor:G-protein coupled receptor homolog US28, Fractalkine, nanobody 7, ...
Authors:Burg, J.S., Jude, K.M., Waghray, D., Garcia, K.C.
Deposit date:2015-01-22
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.886 Å)
Cite:Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
4XT3
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STRUCTURE OF A VIRAL GPCR BOUND TO HUMAN CHEMOKINE CX3CL1
Descriptor:G-protein coupled receptor homolog US28, Fractalkine, UNKNOWN LIGAND, ...
Authors:Burg, J.S., Jude, K.M., Waghray, D., Garcia, K.C.
Deposit date:2015-01-22
Release date:2015-03-04
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (3.801 Å)
Cite:Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
5TCX
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CRYSTAL STRUCTURE OF HUMAN TETRASPANIN CD81
Descriptor:CD81 antigen, CHOLESTEROL
Authors:Zimmerman, B., McMillan, B.J., Seegar, T.C.M., Kruse, A.C., Blacklow, S.C.
Deposit date:2016-09-16
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
Cell, 167, 2016
5UHQ
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STRUCTURE OF A SEMISWEET Q20A MUTANT
Descriptor:Sugar transporter SemiSWEET
Authors:Fastman, N.M., Feng, L.
Deposit date:2017-01-11
Release date:2017-08-02
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Mechanism of Substrate Translocation in an Alternating Access Transporter.
Cell, 169, 2017
5UHS
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STRUCTURE OF A SEMISWEET D57A MUTANT
Descriptor:Sugar transporter SemiSWEET, MONOVACCENIN, BETA-D-GLUCOSE
Authors:Fastman, N.M., Feng, L.
Deposit date:2017-01-11
Release date:2017-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism of Substrate Translocation in an Alternating Access Transporter.
Cell, 169, 2017
6CSM
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CRYSTAL STRUCTURE OF THE NATURAL LIGHT-GATED ANION CHANNEL GTACR1
Descriptor:GtACR1, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSN
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH8.5
Descriptor:iC++, RETINAL, OLEIC ACID, ...
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6CSO
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CRYSTAL STRUCTURE OF THE DESIGNED LIGHT-GATED ANION CHANNEL IC++ AT PH6.5
Descriptor:iC++, RETINAL, OLEIC ACID
Authors:Kato, H.E., Kim, Y., Yamashita, K., Kobilka, B.K., Deisseroth, K.
Deposit date:2018-03-21
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
6DDE
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Zhang, Y., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2018-07-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDF
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2018-07-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DJZ
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HUMAN SIGMA-1 RECEPTOR BOUND TO HALOPERIDOL
Descriptor:Sigma non-opioid intracellular receptor 1, 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, SULFATE ION, ...
Authors:Schmidt, H.R., Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Method:X-RAY DIFFRACTION (3.084 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
6DK0
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HUMAN SIGMA-1 RECEPTOR BOUND TO NE-100
Descriptor:Sigma non-opioid intracellular receptor 1, N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine, SULFATE ION, ...
Authors:Schmidt, H.R., Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
6DK1
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HUMAN SIGMA-1 RECEPTOR BOUND TO (+)-PENTAZOCINE
Descriptor:Sigma non-opioid intracellular receptor 1, (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol, SULFATE ION, ...
Authors:Schmidt, H.R., Kruse, A.C.
Deposit date:2018-05-28
Release date:2018-10-17
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for sigma1receptor ligand recognition.
Nat. Struct. Mol. Biol., 25, 2018
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
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