6WBV

Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc

Summary for 6WBV

• Entry DOI: 10.2210/pdb6wbv/pdb
• Related: 6W4S
• EMDB information: 21539 21599
• Descriptor: Hepcidin, Solute carrier family 40 member 1, Fab45D8 Light Chain, ... (7 entities in total)
• Functional Keywords: ferroportin, transporter, iron, hepcidin, translocase-immune system-hormone complex, translocase/immune system/hormone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 118042.24

Authors

Billesboelle, C.B.,Azumaya, C.M.,Gonen, S.,Powers, A.,Kretsch, R.C.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. (deposition date: 2020-03-27, release date: 2020-09-09, Last modification date: 2020-11-11)

• Primary citation: Billesbolle, C.B.,Azumaya, C.M.,Kretsch, R.C.,Powers, A.S.,Gonen, S.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A.; Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.; Nature, 586:807-811, 2020; PubMed: 32814342; DOI: 10.1038/s41586-020-2668-z

Experimental method

ELECTRON MICROSCOPY (2.5 Å)