6WBV
Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0017046 | molecular_function | peptide hormone binding |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| A | 1903988 | biological_process | iron ion export across plasma membrane |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue AGA A 701 |
| Chain | Residue |
| A | TYR20 |
| A | TYR29 |
| A | SER33 |
| A | THR176 |
| A | ARG179 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue AGA A 702 |
| Chain | Residue |
| A | LYS225 |
| A | LYS229 |
| A | LEU21 |
| A | THR22 |
| A | PHE26 |
| A | LEU27 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CO A 703 |
| Chain | Residue |
| A | ASP39 |
| A | HIS43 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CO A 704 |
| Chain | Residue |
| A | CYS326 |
| A | HIS507 |
| A | HOH806 |
| B | THR25 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR196-HIS202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Peptide: {"description":"Hepcidin-25","featureId":"PRO_0000013379"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Peptide: {"description":"Hepcidin-20","featureId":"PRO_0000013380"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 329 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6W4S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32814342","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
