6WBV
Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Hepcidin | polymer | 25 | 2802.5 | 1 | UniProt (P81172) Pfam (PF06446) In PDB | Homo sapiens | Liver-expressed antimicrobial peptide 1,LEAP-1,Putative liver tumor regressor,PLTR |
| 2 | A | Solute carrier family 40 member 1 | polymer | 605 | 66349.9 | 1 | UniProt (Q9NP59) Pfam (PF06963) In PDB | Homo sapiens (Human) | Ferroportin-1,Iron-regulated transporter 1 |
| 3 | L | Fab45D8 Light Chain | polymer | 218 | 24008.5 | 1 | Mus musculus (mouse) | ||
| 4 | H | Fab45D8 Heavy Chain | polymer | 220 | 23852.6 | 1 | Mus musculus (mouse) | ||
| 5 | A | (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE | non-polymer | 455.5 | 2 | Chemie (AGA) | |||
| 6 | A | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 7 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 1 - 571 (UniProt: Q9NP59)
| PDB | External Database | Details |
|---|---|---|
| Gly 572 | - | expression tag |
| Ser 573 | - | expression tag |
| Gly 574 | - | expression tag |
| Leu 575 | - | expression tag |
| Glu 576 | - | expression tag |
| Val 577 | - | expression tag |
| Leu 578 | - | expression tag |
| Phe 579 | - | expression tag |
| Gln 580 | - | expression tag |
| Gly 581 | - | expression tag |
| Pro 582 | - | expression tag |
| Gly 583 | - | expression tag |
| Ala 584 | - | expression tag |
| Ala 585 | - | expression tag |
| Glu 586 | - | expression tag |
| Asp 587 | - | expression tag |
| Gln 588 | - | expression tag |
| Val 589 | - | expression tag |
| Asp 590 | - | expression tag |
| Pro 591 | - | expression tag |
| Arg 592 | - | expression tag |
| Leu 593 | - | expression tag |
| Ile 594 | - | expression tag |
| Asp 595 | - | expression tag |
| Gly 596 | - | expression tag |
| Lys 597 | - | expression tag |
| His 598 | - | expression tag |
| His 599 | - | expression tag |
| His 600 | - | expression tag |
| His 601 | - | expression tag |
| His 602 | - | expression tag |
| His 603 | - | expression tag |
| His 604 | - | expression tag |
| His 605 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117013.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1028.8 | |
| All* | Total formula weight | 118042.2 |
