8TA2
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
Summary for 8TA2
Entry DOI | 10.2210/pdb8ta2/pdb |
EMDB information | 41126 41127 41128 41129 41130 |
Descriptor | Chloride channel protein 2, 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION (3 entities in total) |
Functional Keywords | chloride, channel, inhibitor, protein, voltage gated, transport protein-inhibitor complex, transport protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 105630.71 |
Authors | Xu, M.,Neelands, T.,Powers, A.S.,Liu, Y.,Miller, S.,Pintilie, G.,Du Bois, J.,Dror, R.O.,Chiu, W.,Maduke, M. (deposition date: 2023-06-26, release date: 2024-01-31, Last modification date: 2024-02-28) |
Primary citation | Xu, M.,Neelands, T.,Powers, A.S.,Liu, Y.,Miller, S.D.,Pintilie, G.D.,Bois, J.D.,Dror, R.O.,Chiu, W.,Maduke, M. CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12:-, 2024 Cited by PubMed: 38345841DOI: 10.7554/eLife.90648 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.74 Å) |
Structure validation
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