8TA2

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42

Summary for 8TA2

Entry DOI	10.2210/pdb8ta2/pdb
EMDB information	41126 41127 41128 41129 41130
Descriptor	Chloride channel protein 2, 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION (3 entities in total)
Functional Keywords	chloride, channel, inhibitor, protein, voltage gated, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	105630.71
Authors	Xu, M.,Neelands, T.,Powers, A.S.,Liu, Y.,Miller, S.,Pintilie, G.,Du Bois, J.,Dror, R.O.,Chiu, W.,Maduke, M. (deposition date: 2023-06-26, release date: 2024-01-31, Last modification date: 2024-02-28)
Primary citation	Xu, M.,Neelands, T.,Powers, A.S.,Liu, Y.,Miller, S.D.,Pintilie, G.D.,Bois, J.D.,Dror, R.O.,Chiu, W.,Maduke, M. CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12:-, 2024 Cited by PubMed: 38345841 DOI: 10.7554/eLife.90648 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation