8TA2

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Chloride channel protein 2	polymer	479	52390.7	2	UniProt (P51788) Pfam (PF00654)	Homo sapiens (human)	ClC-2
2	C, E (A, B)	2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid	non-polymer		389.2	2	Chemie (GH6)
3	D, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104781.3
Non-Polymers*	Number of molecules	4
	Total formula weight	849.4
All*	Total formula weight	105630.7

*Water molecules are not included.