6O3C

Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8

Summary for 6O3C

Entry DOI	10.2210/pdb6o3c/pdb
Descriptor	Smoothened homolog, NbSmo8, PHOSPHATE ION, ... (9 entities in total)
Functional Keywords	gpcr, signaling, hedgehog, smoothened, cholesterol, sag, signaling protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	77051.01
Authors	Deshpande, I.S.,Liang, J.,Hedeen, D.,Roberts, K.J.,Zhang, Y.,Ha, B.,Latorraca, N.R.,Faust, B.,Dror, R.O.,Beachy, P.A.,Myers, B.R.,Manglik, A. (deposition date: 2019-02-26, release date: 2019-07-03, Last modification date: 2023-10-11)
Primary citation	Deshpande, I.,Liang, J.,Hedeen, D.,Roberts, K.J.,Zhang, Y.,Ha, B.,Latorraca, N.R.,Faust, B.,Dror, R.O.,Beachy, P.A.,Myers, B.R.,Manglik, A. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571:284-288, 2019 Cited by PubMed: 31263273 DOI: 10.1038/s41586-019-1355-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation