6O3C

Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0007166	biological_process	cell surface receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	45
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	116
Details	Domain: {"description":"FZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00090","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q99835","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Lipidation: {"description":"Cholesterol aspartate ester","evidences":[{"source":"PubMed","id":"28344083","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31263273","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6O3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---