Irreversible Agonist-Beta2 Adrenoceptor Complex

Summary for 3PDS

DescriptorFusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ... (4 entities in total)
Functional Keywordsgpcr, signaling, beta adrenergic agonist, fusion protein, membrane protein-hydrolase complex, membrane protein/hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Multi- pass membrane protein  P07550
Total number of polymer chains1
Total molecular weight53860.85
Primary citation
Rosenbaum, D.M.,Zhang, C.,Lyons, J.A.,Holl, R.,Aragao, D.,Arlow, D.H.,Rasmussen, S.G.F.,Choi, H.J.,Devree, B.T.,Sunahara, R.K.,Chae, P.S.,Gellman, S.H.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Caffrey, M.,Gmeiner, P.,Kobilka, B.K.
Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469:236-240, 2011
PubMed: 21228876 (PDB entries with the same primary citation)
DOI: 10.1038/nature09665
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.31420.2%2.4%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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