5X7D

Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist

Summary for 5X7D

• Entry DOI: 10.2210/pdb5x7d/pdb
• Descriptor: Chimera protein of Beta-2 adrenergic receptor and Lysozyme, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ... (8 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P07550
• Total number of polymer chains: 1
• Total formula weight: 58946.53

Authors

Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.-C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K. (deposition date: 2017-02-25, release date: 2017-08-16, Last modification date: 2023-10-18)

• Primary citation: Liu, X.,Ahn, S.,Kahsai, A.W.,Meng, K.C.,Latorraca, N.R.,Pani, B.,Venkatakrishnan, A.J.,Masoudi, A.,Weis, W.I.,Dror, R.O.,Chen, X.,Lefkowitz, R.J.,Kobilka, B.K.; Mechanism of intracellular allosteric beta 2AR antagonist revealed by X-ray crystal structure.; Nature, 548:480-484, 2017; PubMed: 28813418; DOI: 10.1038/nature23652

Experimental method

X-RAY DIFFRACTION (2.703 Å)