3VW7

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

Summary for 3VW7

DescriptorProteinase-activated receptor 1, Lysozyme, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
Functional Keywordshigh resolution structure, protease-activated receptor 1, inactive conformation, antagonist vorapaxar, g protein-coupled receptor, signaling protein, membrane protein, thrombin receptor-antagonist complex, signaling protein-antagonist complex, signaling protein/antagonist
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Multi-pass membrane protein P25116
Total number of polymer chains1
Total molecular weight58098.87
Authors
Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K. (deposition date: 2012-08-07, release date: 2012-12-12, Last modification date: 2017-11-22)
Primary citation
Zhang, C.,Srinivasan, Y.,Arlow, D.H.,Fung, J.J.,Palmer, D.,Zheng, Y.,Green, H.F.,Pandey, A.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Coughlin, S.R.,Kobilka, B.K.
High-resolution crystal structure of human protease-activated receptor 1
Nature, 492:387-392, 2012
PubMed: 23222541 (PDB entries with the same primary citation)
DOI: 10.1038/nature11701
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23690.2%1.6%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3vw7
no rotation
Molmil generated image of 3vw7
rotated about x axis by 90°
Molmil generated image of 3vw7
rotated about y axis by 90°