3VW7
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proteinase-activated receptor 1, Lysozyme | polymer | 484 | 54339.0 | 1 | UniProt (P25116) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) | Homo sapiens (human) | PAR-1, Coagulation factor II receptor, Thrombin receptor, Endolysin, Lysis protein, Muramidase |
| 2 | B (A) | ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate | non-polymer | 492.6 | 1 | Chemie (VPX) PubChem (24829427) PubChem (24829428) PubChem (24829430) PubChem (24829431) PubChem (24829596) PubChem (24829597) PubChem (24829599) PubChem (24829767) PubChem (24829768) PubChem (24829769) PubChem (24829770) PubChem (24829933) PubChem (24829936) PubChem (24830101) PubChem (24830102) PubChem (24830104) PubChem (24830105) PubChem (24830266) PubChem (24830268) PubChem (24830269) PubChem (24830429) PubChem (24830430) PubChem (24830432) PubChem (24830433) PubChem (24830590) PubChem (24830591) PubChem (24830592) PubChem (24830593) PubChem (24830594) PubChem (24830599) PubChem (24830746) PubChem (24830747) PubChem (24830748) PubChem (24830749) PubChem (24830753) PubChem (24830756) PubChem (24830899) PubChem (24830900) PubChem (24830901) PubChem (24830902) PubChem (24830903) PubChem (24831058) PubChem (24831059) PubChem (24831060) PubChem (24831061) PubChem (24831217) PubChem (24831219) PubChem (24831221) PubChem (24831378) PubChem (24831379) PubChem (24831380) PubChem (24831381) PubChem (24831382) PubChem (24831538) PubChem (24831539) PubChem (24831540) PubChem (24831541) PubChem (24831697) PubChem (24831699) PubChem (24831701) PubChem (24831859) PubChem (24831860) PubChem (24831861) PubChem (24831862) PubChem (24831863) PubChem (24996772) PubChem (25028259) PubChem (25101901) PubChem (23650648) PubChem (24829766) PubChem (24829934) PubChem (24829429) PubChem (24829935) PubChem (24830598) PubChem (24830755) PubChem (24830754) PubChem (24830265) PubChem (24829598) PubChem (24829600) PubChem (24830752) PubChem (24830745) PubChem (24831057) PubChem (24831537) PubChem (24829932) PubChem (24830267) PubChem (24831218) PubChem (24831698) PubChem (24831220) PubChem (24831700) PubChem (56841711) PubChem (56841712) PubChem (57519546) PubChem (57892463) PubChem (59426515) PubChem (59705311) PubChem (59705312) PubChem (59705313) PubChem (59705314) PubChem (59705315) PubChem (59705317) PubChem (59705322) PubChem (59705324) PubChem (59705325) PubChem (59705326) PubChem (59705327) PubChem (59705328) PubChem (59705331) PubChem (59705333) PubChem (59705334) PubChem (59705335) PubChem (59705336) PubChem (59705340) PubChem (59705343) PubChem (59705346) PubChem (59705347) PubChem (59705349) PubChem (59705350) PubChem (59705352) PubChem (59705356) PubChem (59705357) PubChem (59705360) PubChem (59705362) PubChem (59705365) PubChem (59705368) PubChem (68627740) PubChem (71039194) PubChem (72455102) PubChem (59705310) PubChem (59705330) PubChem (59705321) PubChem (59705342) PubChem (59705316) PubChem (59705339) PubChem (59705329) PubChem (59705354) PubChem (68627738) PubChem (90694505) PubChem (90703979) PubChem (90706053) PubChem (90715868) PubChem (90720922) PubChem (90732411) PubChem (90752552) PubChem (90772294) PubChem (90791306) PubChem (90815655) PubChem (90824891) PubChem (90826555) PubChem (90834500) PubChem (90839420) PubChem (90898351) PubChem (90910410) PubChem (90912898) PubChem (90923273) PubChem (90927043) PubChem (90972609) PubChem (90983234) PubChem (90991010) PubChem (90993213) PubChem (90994802) PubChem (91008657) PubChem (91022572) PubChem (91035142) PubChem (91037071) PubChem (91040419) PubChem (91043189) PubChem (91045334) PubChem (91059380) PubChem (91069870) PubChem (91078753) PubChem (91102425) PubChem (91106390) PubChem (91111172) PubChem (91113316) PubChem (91133600) PubChem (91141646) PubChem (91165612) PubChem (91191291) PubChem (91195303) PubChem (91196636) PubChem (91196997) PubChem (91198453) PubChem (91200550) PubChem (91211985) PubChem (91232265) PubChem (91233344) PubChem (91239306) PubChem (91242902) PubChem (91252896) PubChem (91262187) PubChem (91265553) PubChem (91266694) PubChem (91269296) PubChem (91286572) PubChem (91287518) PubChem (91290956) PubChem (91296703) PubChem (91301202) PubChem (91304353) PubChem (91317187) PubChem (91321212) PubChem (91326966) PubChem (91334363) PubChem (91334463) PubChem (91343620) PubChem (91348691) PubChem (91376735) PubChem (91388973) PubChem (91397184) PubChem (91405937) PubChem (91406102) PubChem (91410413) PubChem (91419779) PubChem (91443327) PubChem (91454412) PubChem (91466729) PubChem (91490514) PubChem (91499526) PubChem (91535417) PubChem (91537865) PubChem (91553614) PubChem (91569115) PubChem (91570348) PubChem (91571664) PubChem (91574030) PubChem (90753977) PubChem (91038725) PubChem (90854677) PubChem (90912774) PubChem (90931848) PubChem (90950127) PubChem (91151770) PubChem (90987682) PubChem (91026458) PubChem (91249093) PubChem (91174308) PubChem (91135150) PubChem (91202209) PubChem (91210284) PubChem (91236024) PubChem (91283918) PubChem (91311077) PubChem (91349320) PubChem (91390848) PubChem (91369967) PubChem (91389433) PubChem (91415773) PubChem (91431740) PubChem (91513007) PubChem (91449441) PubChem (91456314) PubChem (91464968) PubChem (91586008) PubChem (91586082) PubChem (91591472) PubChem (91600310) PubChem (91612333) PubChem (91613337) PubChem (143673931) PubChem (117590638) PubChem (117841714) PubChem (121595945) PubChem (122172969) PubChem (10028615) PubChem (10077130) PubChem (126659484) PubChem (167455086) PubChem (129627201) PubChem (130324376) PubChem (138107138) PubChem (143673870) PubChem (143673885) PubChem (143673954) PubChem (143674001) PubChem (143674093) PubChem (143674112) PubChem (164146961) | |||
| 3 | C, D, E, F, G... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 9 | Chemie (OLC) PubChem (25021708) PubChem (46840179) PubChem (54294271) PubChem (54294270) PubChem (33022) PubChem (5283468) PubChem (5364833) PubChem (11451146) PubChem (12178130) | |||
| 4 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 5 | M (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 6 | N (A) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 86 - 301 (UniProt: P25116)
A: 1002 - 1161 (UniProt: P00720)
A: 303 - 395 (UniProt: P25116)
| PDB | External Database | Details |
|---|---|---|
| Ser 83 | - | expression tag |
| Gly 84 | - | expression tag |
| Thr 85 | - | expression tag |
| Gly 250 | Asn 250 | engineered mutation |
| Ser 259 | Asn 259 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 1020 | Asp 20 | engineered mutation |
| Thr 1054 | Cys 54 | engineered mutation |
| Ala 1097 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 396 | - | expression tag |
| Tyr 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54339.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3759.9 | |
| All* | Total formula weight | 58098.9 |
