3VW7
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proteinase-activated receptor 1, Lysozyme | polymer | 484 | 54339.0 | 1 | UniProt (P25116) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (human) | PAR-1, Coagulation factor II receptor, Thrombin receptor, Endolysin, Lysis protein, Muramidase |
2 | A | ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate | non-polymer | 492.6 | 1 | Chemie (VPX) | |||
3 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 9 | Chemie (OLC) | |||
4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
6 | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 86 - 301 (UniProt: P25116)
A: 1002 - 1161 (UniProt: P00720)
A: 303 - 395 (UniProt: P25116)
PDB | External Database | Details |
---|---|---|
Ser 83 | - | expression tag |
Gly 84 | - | expression tag |
Thr 85 | - | expression tag |
Gly 250 | Asn 250 | engineered mutation |
Ser 259 | Asn 259 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 1020 | Asp 20 | engineered mutation |
Thr 1054 | Cys 54 | engineered mutation |
Ala 1097 | Cys 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Cys 396 | - | expression tag |
Tyr 397 | - | expression tag |
His 398 | - | expression tag |
His 399 | - | expression tag |
His 400 | - | expression tag |
His 401 | - | expression tag |
His 402 | - | expression tag |
His 403 | - | expression tag |
His 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54339.0 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 3759.9 | |
All* | Total formula weight | 58098.9 |