3VW7

Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proteinase-activated receptor 1, Lysozyme	polymer	484	54339.0	1	UniProt (P25116) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (human)	PAR-1, Coagulation factor II receptor, Thrombin receptor, Endolysin, Lysis protein, Muramidase
2	A	ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate	non-polymer		492.6	1	Chemie (VPX)
3	A	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	9	Chemie (OLC)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 86 - 301 (UniProt: P25116)

PDB	External Database	Details
Ser 83	-	expression tag
Gly 84	-	expression tag
Thr 85	-	expression tag
Gly 250	Asn 250	engineered mutation
Ser 259	Asn 259	engineered mutation

A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Asn 1020	Asp 20	engineered mutation
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 303 - 395 (UniProt: P25116)

PDB	External Database	Details
Cys 396	-	expression tag
Tyr 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54339.0
Non-Polymers*	Number of molecules	12
	Total formula weight	3759.9
All*	Total formula weight	58098.9

*Water molecules are not included.