5WIU

Structure of the human D4 Dopamine receptor in complex with Nemonapride

Summary for 5WIU

• Entry DOI: 10.2210/pdb5wiu/pdb
• Related: 5WIV
• Descriptor: D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: gpcr, dopamine receptor, antagonist, sodium, signaling protein-antagonist complex, signaling protein/antagonist
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 49568.74

Authors

Wacker, D.,Wang, S.,Levit, A.,Che, T.,Betz, R.M.,McCorvy, J.D.,Venkatakrishnan, A.J.,Huang, X.-P.,Dror, R.O.,Shoichet, B.K.,Roth, B.L. (deposition date: 2017-07-20, release date: 2017-10-18, Last modification date: 2023-10-04)

• Primary citation: Wang, S.,Wacker, D.,Levit, A.,Che, T.,Betz, R.M.,McCorvy, J.D.,Venkatakrishnan, A.J.,Huang, X.P.,Dror, R.O.,Shoichet, B.K.,Roth, B.L.; D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.; Science, 358:381-386, 2017; PubMed: 29051383; DOI: 10.1126/science.aan5468

Experimental method

X-RAY DIFFRACTION (1.962 Å)