5WIU
Structure of the human D4 Dopamine receptor in complex with Nemonapride
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | D(4) dopamine receptor, soluble cytochrome b562 chimera | polymer | 422 | 45306.6 | 1 | UniProt (P21917) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | D(2C) dopamine receptor, Dopamine D4 receptor, Cytochrome b-562 |
| 2 | B (A) | Nemonapride | non-polymer | 387.9 | 1 | Chemie (AQD) | |||
| 3 | C, D, E (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 4 | F, G, H, I, J... (A) | OLEIC ACID | non-polymer | 282.5 | 9 | Chemie (OLA) | |||
| 5 | O, P, Q, R, S... (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 9 | Chemie (PEG) | |||
| 6 | X (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | Y (A) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 1 - 1001 (UniProt: P21917)
A: 1002 - 1106 (UniProt: P0ABE7)
A: 383 - 467 (UniProt: P21917)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Thr 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45306.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 4262.1 | |
| All* | Total formula weight | 49568.7 |
