6W4S

Structure of apo human ferroportin in lipid nanodisc

Summary for 6W4S

Entry DOI	10.2210/pdb6w4s/pdb
EMDB information	21539
Descriptor	Solute carrier family 40 member 1, Fab45D8 Heavy Chain, Fab45D8 Light Chain (3 entities in total)
Functional Keywords	ferroportin, transporter, iron, hepcidin, transport protein-immune system complex, transport protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	114211.01
Authors	Billesboelle, C.B.,Azumaya, C.M.,Gonen, S.,Powers, A.,Kretsch, R.C.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. (deposition date: 2020-03-11, release date: 2020-09-09, Last modification date: 2020-11-11)
Primary citation	Billesbolle, C.B.,Azumaya, C.M.,Kretsch, R.C.,Powers, A.S.,Gonen, S.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature, 586:807-811, 2020 Cited by PubMed: 32814342 DOI: 10.1038/s41586-020-2668-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation