6W4V

Structure of anti-ferroportin Fab45D8

Summary for 6W4V

• Entry DOI: 10.2210/pdb6w4v/pdb
• Related: 6W4S
• EMDB information: 21539
• Descriptor: Fab45D8 Light Chain, Fab45D8 Heavy Chain, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: ferroportin, transporter, iron, hepcidin, antibody, fab, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48725.06

Authors

Billesboelle, C.B.,Azumaya, C.M.,Gonen, S.,Powers, A.,Kretsch, R.C.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A. (deposition date: 2020-03-11, release date: 2020-09-09, Last modification date: 2023-10-18)

• Primary citation: Billesbolle, C.B.,Azumaya, C.M.,Kretsch, R.C.,Powers, A.S.,Gonen, S.,Schneider, S.,Arvedson, T.,Dror, R.O.,Cheng, Y.,Manglik, A.; Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.; Nature, 586:807-811, 2020; PubMed: 32814342; DOI: 10.1038/s41586-020-2668-z

Experimental method

X-RAY DIFFRACTION (2.1 Å)