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PDB: 51 results

4XLI
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Crystal structure of Abl2/Arg kinase in complex with dasatinib
Descriptor: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Non-specific protein-tyrosine kinase, ZINC ION
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2015-01-13
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the ABL2/ARG kinase in complex with dasatinib.
Acta Crystallogr.,Sect.F, 71, 2015
7KJX
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BU of 7kjx by Molmil
Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 viral RNA fragment, MAGNESIUM ION, ...
Authors:Ha, B, Larsen, K.P, Zhang, J, Fu, Z, Montabana, E, Jackson, L.N, Chen, D.H, Puglisi, E.V.
Deposit date:2020-10-26
Release date:2021-03-17
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Nat Commun, 12, 2021
7S46
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BU of 7s46 by Molmil
PAK4cat (D440N/S474E) in complex with Integrin beta5 760-770 peptide
Descriptor: Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
7S48
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PAK4cat in complex with Integrin beta5 760-770 peptide
Descriptor: Integrin beta-5, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
7S47
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Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E)
Descriptor: Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2021-09-08
Release date:2022-11-09
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
7KJV
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BU of 7kjv by Molmil
Structure of HIV-1 reverse transcriptase initiation complex core
Descriptor: HIV-1 viral RNA fragment, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ...
Authors:Ha, B, Larsen, K.P, Zhang, J, Fu, Z, Montabana, E, Jackson, L.N, Chen, D.H, Puglisi, E.V.
Deposit date:2020-10-26
Release date:2021-03-17
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Nat Commun, 12, 2021
7KJW
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BU of 7kjw by Molmil
Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz
Descriptor: (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, HIV-1 viral RNA fragment, MAGNESIUM ION, ...
Authors:Ha, B, Larsen, K.P, Zhang, J, Fu, Z, Montabana, E, Jackson, L.N, Chen, D.H, Puglisi, E.V.
Deposit date:2020-10-26
Release date:2021-03-17
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Nat Commun, 12, 2021
5UPK
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BU of 5upk by Molmil
CDC42 binds PAK4 via an extended GTPase-effector interface - 3 peptide: PAK4cat, PAK4-N45, CDC42
Descriptor: Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2017-02-03
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CDC42 binds PAK4 via an extended GTPase-effector interface.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5UPL
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CDC42 binds PAK4 via an extended GTPase-effector inteface - 2 peptide: PAK4FL, CDC42 - UNREFINED
Descriptor: Cell division control protein 42 homolog, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2017-02-03
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:CDC42 binds PAK4 via an extended GTPase-effector interface.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BHC
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BU of 6bhc by Molmil
Crystal structure of pseduokinase PEAK1 (Sugen Kinase 269)
Descriptor: Pseudopodium-enriched atypical kinase 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2017-10-30
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.
J. Biol. Chem., 293, 2018
4FIE
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BU of 4fie by Molmil
Full-length human PAK4
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIG
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BU of 4fig by Molmil
Catalytic domain of human PAK4
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIF
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BU of 4fif by Molmil
Catalytic domain of human PAK4 with RPKPLVDP peptide
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4JDI
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BU of 4jdi by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide S peptide substrate
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Paktide S, ...
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2013-02-25
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JDK
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BU of 4jdk by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide S peptide substrate
Descriptor: Paktide S, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2013-02-25
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4FIH
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BU of 4fih by Molmil
Catalytic domain of human PAK4 with QKFTGLPRQW peptide
Descriptor: Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIJ
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BU of 4fij by Molmil
Catalytic domain of human PAK4
Descriptor: Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FII
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BU of 4fii by Molmil
Catalytic domain of human PAK4 with RPKPLVDP peptide
Descriptor: Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GZM
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BU of 4gzm by Molmil
Crystal structure of RAC1 F28L mutant
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-09-06
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GZL
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BU of 4gzl by Molmil
Crystal structure of RAC1 Q61L mutant
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-09-06
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JDJ
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BU of 4jdj by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide T peptide substrate
Descriptor: Paktide T, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2013-02-25
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
4JDH
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BU of 4jdh by Molmil
Crystal structure of Serine/threonine-protein kinase PAK 4 in complex with Paktide T peptide substrate
Descriptor: Paktide T, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2013-02-25
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Mol.Cell, 53, 2014
3SBD
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BU of 3sbd by Molmil
Crystal structure of RAC1 P29S mutant
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-06-03
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
3TH5
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BU of 3th5 by Molmil
Crystal structure of wild-type RAC1
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2011-08-18
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
2Z84
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BU of 2z84 by Molmil
Insights from crystal and solution structures of mouse UfSP1
Descriptor: Ufm1-specific protease 1
Authors:Ha, B.H, Ahn, H.C, Kang, S.H, Tanaka, K, Chung, C.H, Kim, E.E.
Deposit date:2007-08-30
Release date:2008-03-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for Ufm1 processing by UfSP1
J. Biol. Chem., 283, 2008

 

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