8SMV

GPR161 Gs heterotrimer

Summary for 8SMV

Entry DOI	10.2210/pdb8smv/pdb
EMDB information	40603
Descriptor	G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, ... (6 entities in total)
Functional Keywords	gpcr, orphan, active, hedgehog, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	154510.47
Authors	Hoppe, N.,Manglik, A.,Harrison, S. (deposition date: 2023-04-26, release date: 2024-02-21, Last modification date: 2024-03-20)
Primary citation	Hoppe, N.,Harrison, S.,Hwang, S.H.,Chen, Z.,Karelina, M.,Deshpande, I.,Suomivuori, C.M.,Palicharla, V.R.,Berry, S.P.,Tschaikner, P.,Regele, D.,Covey, D.F.,Stefan, E.,Marks, D.S.,Reiter, J.,Dror, R.O.,Evers, A.S.,Mukhopadhyay, S.,Manglik, A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv, 2023 Cited by PubMed: 37292845 DOI: 10.1101/2023.05.23.540554 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation