8SMV
GPR161 Gs heterotrimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | G-protein coupled receptor 161 | polymer | 540 | 59869.9 | 1 | UniProt (Q8N6U8) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor RE2 |
| 2 | B (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 3 | C (N) | Nanobody 35 | polymer | 142 | 15398.1 | 1 | Lama glama (llama) | ||
| 4 | D (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 261 | 30137.0 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 5 | E (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 370 | 40857.6 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 6 | F (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (176980071) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (59274407) PubChem (45044259) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (49853509) PubChem (50990013) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (52934537) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (56621683) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (138967089) PubChem (139566851) PubChem (15939944) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (171828367) PubChem (173516975) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (304) PubChem (124225449) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (124429284) PubChem (638019) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (130459183) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) |
Sequence modifications
R: 1 - 529 (UniProt: Q8N6U8)
A: 5 - 64 (UniProt: P63092)
A: 204 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Asp 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Val -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| Asp 249 | Ala 249 | conflict |
| Asp 252 | Ser 252 | conflict |
| - | Asn 254 | deletion |
| - | Met 255 | deletion |
| - | Val 256 | deletion |
| - | Ile 257 | deletion |
| - | Arg 258 | deletion |
| - | Glu 259 | deletion |
| - | Asp 260 | deletion |
| - | Asn 261 | deletion |
| - | Gln 262 | deletion |
| - | Thr 263 | deletion |
| Ala 372 | Ile 372 | conflict |
| Ile 375 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -29 | - | initiating methionine |
| His -28 | - | expression tag |
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Glu -21 | - | expression tag |
| Val -20 | - | expression tag |
| Leu -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Gln -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Pro -15 | - | expression tag |
| Glu -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Arg -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Ile -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 154123.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 154510.5 |
