7RMG

Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70

Summary for 7RMG

Entry DOI	10.2210/pdb7rmg/pdb
EMDB information	24569
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, with certain residues mutated to match Guanine nucleotide-binding protein G(q) subunit, Substance-P receptor, Substance P, ... (6 entities in total)
Functional Keywords	substance p, g protein, gpcr, neurokinin, tachykinin, signaling protein, signaling protein-membrane protein complex, signaling protein/membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	139090.85
Authors	Harris, J.A.,Faust, B.,Gondin, A.B.,Daemgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.,Manglik, A. (deposition date: 2021-07-27, release date: 2021-11-03, Last modification date: 2022-01-05)
Primary citation	Harris, J.A.,Faust, B.,Gondin, A.B.,Damgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.M.,Manglik, A. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18:109-115, 2022 Cited by PubMed: 34711980 DOI: 10.1038/s41589-021-00890-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation