5UBM
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![BU of 5ubm by Molmil](/molmil-images/mine/5ubm) | |
7PQN
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![BU of 7pqn by Molmil](/molmil-images/mine/7pqn) | Catalytic fragment of MASP-2 in complex with ecotin | 分子名称: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 2 A chain, ... | 著者 | Harmat, V, Fodor, K, Heja, D. | 登録日 | 2021-09-17 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.400015 Å) | 主引用文献 | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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7PQO
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![BU of 7pqo by Molmil](/molmil-images/mine/7pqo) | Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin | 分子名称: | Ecotin, GLYCEROL, Mannan-binding lectin serine protease 1, ... | 著者 | Harmat, V, Fodor, K, Heja, D. | 登録日 | 2021-09-17 | 公開日 | 2022-05-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298, 2022
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7NOZ
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![BU of 7noz by Molmil](/molmil-images/mine/7noz) | Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ... | 著者 | Lorenzen, J, Pedersen, D.V, Andersen, G.R. | 登録日 | 2021-02-26 | 公開日 | 2022-07-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31, 2022
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4IGD
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![BU of 4igd by Molmil](/molmil-images/mine/4igd) | Crystal structure of the zymogen catalytic region of Human MASP-1 | 分子名称: | GLYCEROL, Mannan-binding lectin serine protease 1 | 著者 | Harmat, V, Megyeri, M, Vegh, A, Dobo, J. | 登録日 | 2012-12-17 | 公開日 | 2013-02-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway J.Biol.Chem., 288, 2013
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5WTB
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![BU of 5wtb by Molmil](/molmil-images/mine/5wtb) | Complex Structure of Staphylococcus aureus SdrE with human complement factor H | 分子名称: | Peptide from Complement factor H, Serine-aspartate repeat-containing protein E | 著者 | Wu, M, Zhang, Y, Hang, T, Wang, C, Yang, Y, Zang, J, Zhang, M, Zhang, X. | 登録日 | 2016-12-10 | 公開日 | 2017-07-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion Biochem. J., 474, 2017
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2QY0
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![BU of 2qy0 by Molmil](/molmil-images/mine/2qy0) | Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts | 分子名称: | Complement C1r subcomponent, GLYCEROL | 著者 | Kardos, J, Harmat, V, Pallo, A, Barabas, O, Szilagyi, K, Graf, L, Naray-Szabo, G, Goto, Y, Zavodszky, P, Gal, P. | 登録日 | 2007-08-13 | 公開日 | 2008-02-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol.Immunol., 45, 2008
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8D8O
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![BU of 8d8o by Molmil](/molmil-images/mine/8d8o) | Cryo-EM structure of substrate unbound PAPP-A | 分子名称: | Pappalysin-1, ZINC ION | 著者 | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | 登録日 | 2022-06-08 | 公開日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition Nat Commun, 13, 2022
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5O35
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![BU of 5o35 by Molmil](/molmil-images/mine/5o35) | Structure of complement proteins complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | 登録日 | 2017-05-23 | 公開日 | 2017-06-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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5NBQ
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![BU of 5nbq by Molmil](/molmil-images/mine/5nbq) | The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg | 分子名称: | Complement C3, Complement factor H, Outer surface protein E, ... | 著者 | Kolodziejczyk, R, Mikula, K.M, Kotila, T.M, Postis, V.L.G, Sakari, J.T, Meri, T. | 登録日 | 2017-03-02 | 公開日 | 2017-12-06 | 最終更新日 | 2017-12-13 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. PLoS ONE, 12, 2017
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8HGH
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![BU of 8hgh by Molmil](/molmil-images/mine/8hgh) | Structure of 2:2 PAPP-A.STC2 complex | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION | 著者 | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | 登録日 | 2022-11-14 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov, 8, 2022
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8GMN
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![BU of 8gmn by Molmil](/molmil-images/mine/8gmn) | Crystal structure of human C1s in complex with inhibitor | 分子名称: | Complement C1s subcomponent, SULFATE ION, [4-(1-aminophthalazin-6-yl)piperazin-1-yl](2-methylphenyl)methanone | 著者 | Dougan, D.R, Lane, W. | 登録日 | 2023-03-26 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J.Med.Chem., 66, 2023
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8ENU
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![BU of 8enu by Molmil](/molmil-images/mine/8enu) | Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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1MD7
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![BU of 1md7 by Molmil](/molmil-images/mine/1md7) | Monomeric structure of the zymogen of complement protease C1r | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C1R COMPLEMENT SERINE PROTEASE | 著者 | Budayova-Spano, M, Grabarse, W, Thielens, N.M, Hillen, H, Lacroix, M, Schmidt, M, Fontecilla-Camps, J, Arlaud, G.J, Gaboriaud, C. | 登録日 | 2002-08-07 | 公開日 | 2003-08-07 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism Structure, 10, 2002
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6XZ6
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![BU of 6xz6 by Molmil](/molmil-images/mine/6xz6) | |
6V06
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![BU of 6v06 by Molmil](/molmil-images/mine/6v06) | Crystal structure of Beta-2 glycoprotein I purified from plasma (pB2GPI) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-glycoprotein 1, ... | 著者 | Chen, Z, Ruben, E.A, Planer, W, Chinnaraj, M, Zuo, X, Pengo, V, Macor, P, Tedesco, F, Pozzi, N. | 登録日 | 2019-11-18 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J.Biol.Chem., 295, 2020
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6V09
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![BU of 6v09 by Molmil](/molmil-images/mine/6v09) | Crystal structure of human recombinant Beta-2 glycoprotein I short tag (ST-B2GPI) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1, SULFATE ION, ... | 著者 | Chen, Z, Ruben, E.A, Planer, W, Chinnaraj, M, Zuo, X, Pengo, V, Macor, P, Tedesco, F, Pozzi, N. | 登録日 | 2019-11-18 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J.Biol.Chem., 295, 2020
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6XSD
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![BU of 6xsd by Molmil](/molmil-images/mine/6xsd) | Patient-derived B2GPI | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1 | 著者 | Klenotic, P.A, Yu, E.W.Y. | 登録日 | 2020-07-15 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | B2-Glycoprotein I and it's role in APS To Be Published
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6XST
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![BU of 6xst by Molmil](/molmil-images/mine/6xst) | |
7JIK
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![BU of 7jik by Molmil](/molmil-images/mine/7jik) | Human recombinant Beta-2-Glycoprotein 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1, ... | 著者 | Klenotic, P.A, Yu, E.W.Y. | 登録日 | 2020-07-23 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Beta-2-Glycoprotein I and it's role in APS To Be Published
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8SL1
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![BU of 8sl1 by Molmil](/molmil-images/mine/8sl1) | Cryo-EM structure of PAPP-A2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Judge, R.A, Stoll, V.S, Eaton, D, Hao, Q, Bratkowski, M.A. | 登録日 | 2023-04-20 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition. Commun Chem, 6, 2023
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6V08
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![BU of 6v08 by Molmil](/molmil-images/mine/6v08) | Crystal structure of human recombinant Beta-2 glycoprotein I (hrB2GPI) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-glycoprotein 1, SULFATE ION, ... | 著者 | Chen, Z, Ruben, E.A, Planer, W, Chinnaraj, M, Zuo, X, Pengo, V, Macor, P, Tedesco, F, Pozzi, N. | 登録日 | 2019-11-18 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome. J.Biol.Chem., 295, 2020
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8SM0
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![BU of 8sm0 by Molmil](/molmil-images/mine/8sm0) | Crystal structure of human complement receptor 2 (CD21) in complex with Epstein-Barr virus major glycoprotein gp350 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement receptor type 2, Envelope glycoprotein gp350, ... | 著者 | Chen, W.-H, Bu, W, Cohen, J.I, Kanekiyo, M, Joyce, M.G. | 登録日 | 2023-04-25 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structural Basis For Receptor Engagement And Virus Neutralization Through Epstein-Barr Virus Gp350 To Be Published
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6VWU
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![BU of 6vwu by Molmil](/molmil-images/mine/6vwu) | |
8TYP
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![BU of 8typ by Molmil](/molmil-images/mine/8typ) | Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide | 分子名称: | 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Geisbrecht, B.V. | 登録日 | 2023-08-25 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol., 212, 2024
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