8TYP

Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide

Summary for 8TYP

Entry DOI	10.2210/pdb8typ/pdb
Descriptor	Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, ... (4 entities in total)
Functional Keywords	complement, protease, inhibitor, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39037.83
Authors	Geisbrecht, B.V. (deposition date: 2023-08-25, release date: 2023-11-29, Last modification date: 2024-02-14)
Primary citation	Xu, X.,Herdendorf, T.J.,Duan, H.,Rohlik, D.L.,Roy, S.,Zhou, H.,Alkhateeb, H.,Khandelwal, S.,Zhou, Q.,Li, P.,Arepally, G.M.,Walker, J.K.,Garcia, B.L.,Geisbrecht, B.V. Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol., 212:689-701, 2024 Cited by PubMed: 38149922 DOI: 10.4049/jimmunol.2300630 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation