8HGH

Structure of 2:2 PAPP-A.STC2 complex

Summary for 8HGH

Entry DOI	10.2210/pdb8hgh/pdb
EMDB information	34739
Descriptor	Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION (3 entities in total)
Functional Keywords	hydrolase, metal binding protein
Biological source	Escherichia coli K-12 More
Total number of polymer chains	4
Total formula weight	499524.88
Authors	Zhong, Q.H.,Chu, H.L.,Wang, G.P.,Zhang, C.,Wei, Y.,Qiao, J.,Hang, J. (deposition date: 2022-11-14, release date: 2023-01-11)
Primary citation	Zhong, Q.,Chu, H.,Wang, G.,Zhang, C.,Li, R.,Guo, F.,Meng, X.,Lei, X.,Zhou, Y.,Ren, R.,Tao, L.,Li, N.,Gao, N.,Wei, Y.,Qiao, J.,Hang, J. Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov, 8:137-137, 2022 Cited by PubMed: 36550107 DOI: 10.1038/s41421-022-00502-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.16 Å)

Structure validation