8HGH

Structure of 2:2 PAPP-A.STC2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1	polymer	1944	216398.3	2	UniProt (P0AEX9) UniProt (Q13219) Pfam (PF01547) Pfam (PF13385) Pfam (PF05572) Pfam (PF00084)	Escherichia coli K-12	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Insulin-like growth factor-dependent IGF-binding protein 4 protease,IGF-dependent IGFBP-4 protease,IGFBP-4ase,Pregnancy-associated plasma protein A,PAPP-A
2	C, D (C, G)	Stanniocalcin-2	polymer	302	33298.7	2	UniProt (O76061) Pfam (PF03298)	Homo sapiens (human)	STC-2,Stanniocalcin-related protein,STC-related protein,STCRP
3	E, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, B: -381 - -16 (UniProt: P0AEX9)

PDB	External Database	Details
Ala -396	-	expression tag
Ala -395	-	expression tag
Ser -394	-	expression tag
His -393	-	expression tag
His -392	-	expression tag
His -391	-	expression tag
His -390	-	expression tag
His -389	-	expression tag
His -388	-	expression tag
His -387	-	expression tag
His -386	-	expression tag
His -385	-	expression tag
His -384	-	expression tag
Ser -383	-	expression tag
Gly -382	-	expression tag
Asp -15	-	linker
Tyr -14	-	linker
Asp -13	-	linker
Ile -12	-	linker
Pro -11	-	linker
Thr -10	-	linker
Thr -9	-	linker
Glu -8	-	linker
Asn -7	-	linker
Leu -6	-	linker
Tyr -5	-	linker
Phe -4	-	linker
Gln -3	-	linker
Gly -2	-	linker
Glu -1	-	linker
Phe 0	-	linker

A, B: 1 - 1547 (UniProt: Q13219)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	499394.1
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	499524.9

*Water molecules are not included.