2QY0
Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts
Summary for 2QY0
Entry DOI | 10.2210/pdb2qy0/pdb |
Descriptor | Complement C1r subcomponent, GLYCEROL, ... (4 entities in total) |
Functional Keywords | complement, serine protease, beta barrel, complement pathway, egf-like domain, glycoprotein, hydrolase, hydroxylation, immune response, innate immunity, phosphorylation, sushi |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 91851.70 |
Authors | Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P. (deposition date: 2007-08-13, release date: 2008-02-05, Last modification date: 2023-08-30) |
Primary citation | Kardos, J.,Harmat, V.,Pallo, A.,Barabas, O.,Szilagyi, K.,Graf, L.,Naray-Szabo, G.,Goto, Y.,Zavodszky, P.,Gal, P. Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol.Immunol., 45:1752-1760, 2008 Cited by PubMed: 17996945DOI: 10.1016/j.molimm.2007.09.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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