7NOZ

Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP

Summary for 7NOZ

Entry DOI	10.2210/pdb7noz/pdb
Descriptor	Complement C3 beta chain, alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
Functional Keywords	protease, complement, cascade, proconvertase, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	317060.38
Authors	Lorenzen, J.,Pedersen, D.V.,Andersen, G.R. (deposition date: 2021-02-26, release date: 2022-07-27, Last modification date: 2024-01-31)
Primary citation	Lorentzen, J.,Pedersen, D.V.,Gadeberg, T.A.F.,Andersen, G.R. Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31:e4432-e4432, 2022 Cited by PubMed: 36173177 DOI: 10.1002/pro.4432 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation