7NOZ
Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Complement C3 beta chain | polymer | 645 | 71393.3 | 1 | UniProt (P01024) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) | Homo sapiens (human) | |
| 2 | B (B) | Complement C3 alpha chain | polymer | 912 | 103759.8 | 1 | UniProt (P01024) Pfam (PF07677) Pfam (PF01759) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) | Homo sapiens (human) | |
| 3 | C (C) | Properdin | polymer | 163 | 17745.0 | 1 | UniProt (P27918) Pfam (PF18487) Pfam (PF00090) | Homo sapiens (human) | Complement factor P |
| 4 | D (D) | Properdin | polymer | 207 | 22958.3 | 1 | UniProt (P27918) Pfam (PF00090) Pfam (PF22195) | Homo sapiens (human) | Complement factor P |
| 5 | E (F) | Complement factor B | polymer | 731 | 82084.6 | 1 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | Homo sapiens (human) | C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B |
| 6 | F (R) | hFPNb1 nanobody | polymer | 124 | 13557.1 | 1 | Lama glama | ||
| 7 | G, H, M (E, G, L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 8 | I, J, K (H, I, J) | beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | branched | 326.3 | 3 | In PDB GlyTouCan (G36855WW) | |||
| 9 | L, N (K, M) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 10 | O, P, Q, R, S... (C, D) | alpha-D-mannopyranose | non-polymer | 180.2 | 6 | Chemie (MAN) | |||
| 11 | U (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 12 | V (F) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 13 | W, X (B, F) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 752 - 1663 (UniProt: P01024)
D: 255 - 461 (UniProt: P27918)
F: 35 - 764 (UniProt: P00751)
| PDB | External Database | Details |
|---|---|---|
| Glu 1013 | Gln 1013 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 255 | Pro 255 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 279 | Asp 279 | engineered mutation |
| Ala 765 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 311498.1 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 4235.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1326.4 | |
| All* | Total formula weight | 317060.4 |
