7NOZ
Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| F | 0001848 | molecular_function | complement binding |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006508 | biological_process | proteolysis |
| F | 0006956 | biological_process | complement activation |
| F | 0006957 | biological_process | complement activation, alternative pathway |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0009617 | biological_process | response to bacterium |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| F | LEU522-CYS527 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI |
| Chain | Residue | Details |
| F | ASN693-ILE704 |
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM |
| Chain | Residue | Details |
| B | PRO1007-MET1015 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| F | HIS526 | |
| F | ASP576 | |
| F | SER699 | |
| D | TRP324 | |
| D | TRP382 | |
| D | TRP385 | |
| D | TRP388 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| F | ASN122 | |
| F | ASN285 | |
| A | SER297 | |
| A | SER303 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| F | ASN142 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911 |
| Chain | Residue | Details |
| F | LYS291 | |
| B | SER1321 | |
| B | SER1573 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| F | ASN378 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| B | ASN1617 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) |
| Chain | Residue | Details |
| B | CYS1010 | |
| B | GLU1013 |
