6VWU
X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha
Summary for 6VWU
| Entry DOI | 10.2210/pdb6vwu/pdb |
| Descriptor | Interleukin-2,Interleukin-2 receptor subunit alpha (1 entity in total) |
| Functional Keywords | circular permutation, alks 4230, cytokine |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 34464.32 |
| Authors | Losey, H.C. (deposition date: 2020-02-20, release date: 2020-04-29, Last modification date: 2023-10-11) |
| Primary citation | Lopes, J.E.,Fisher, J.L.,Flick, H.L.,Wang, C.,Sun, L.,Ernstoff, M.S.,Alvarez, J.C.,Losey, H.C. ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer, 8:-, 2020 Cited by PubMed: 32317293DOI: 10.1136/jitc-2020-000673 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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