6VWU

X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-2,Interleukin-2 receptor subunit alpha	polymer	303	34464.3	1	UniProt (Q6QWN0) UniProt (P60568) UniProt (P01589) Pfam (PF00715) Pfam (PF00084)	Homo sapiens (Human)	IL-2,IL-2,T-cell growth factor,TCGF,IL2-RA,TAC antigen,p55

Sequence modifications

A: 1 - 59 (UniProt: Q6QWN0)

PDB	External Database	Details
Gly 60	-	linker
Gly 61	-	linker

A: 62 - 132 (UniProt: P60568)

PDB	External Database	Details
Gly 133	-	linker
Ser 134	-	linker
Gly 135	-	linker
Gly 136	-	linker
Gly 137	-	linker
Ser 138	-	linker

A: 139 - 303 (UniProt: P01589)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34464.3
All*	Total formula weight	34464.3

*Water molecules are not included.