6VWU
X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004911 | molecular_function | interleukin-2 receptor activity |
| A | 0005134 | molecular_function | interleukin-2 receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006955 | biological_process | immune response |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0019976 | molecular_function | interleukin-2 binding |
Functional Information from PROSITE/UniProt
| site_id | PS00424 |
| Number of Residues | 13 |
| Details | INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL |
| Chain | Residue | Details |
| A | THR109-LEU121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 62 |
| Details | Domain: {"description":"Sushi 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3134887","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","featureId":"CAR_000051","evidences":[{"source":"PubMed","id":"2793860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6333684","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
