7PQO

Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin

This is a non-PDB format compatible entry.

Summary for 7PQO

• Entry DOI: 10.2210/pdb7pqo/pdb
• Descriptor: Mannan-binding lectin serine protease 1, Ecotin, GLYCEROL, ... (4 entities in total)
• Functional Keywords: serine protease, complement, inhibitor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 191944.85

Authors

Harmat, V.,Fodor, K.,Heja, D. (deposition date: 2021-09-17, release date: 2022-05-18, Last modification date: 2024-01-31)

• Primary citation: Nagy, Z.A.,Heja, D.,Bencze, D.,Kiss, B.,Boros, E.,Szakacs, D.,Fodor, K.,Wilmanns, M.,Kocsis, A.,Dobo, J.,Gal, P.,Harmat, V.,Pal, G.; Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.; J.Biol.Chem., 298:101985-101985, 2022; PubMed: 35483450; DOI: 10.1016/j.jbc.2022.101985

Experimental method

X-RAY DIFFRACTION (3.39 Å)