8SL1

Cryo-EM structure of PAPP-A2

Summary for 8SL1

• Entry DOI: 10.2210/pdb8sl1/pdb
• EMDB information: 40571
• Descriptor: Pappalysin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• Functional Keywords: protease, zinc binding, growth factor signaling, peptide binding, hydrolase, peptide binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 175050.94

Authors

Judge, R.A.,Stoll, V.S.,Eaton, D.,Hao, Q.,Bratkowski, M.A. (deposition date: 2023-04-20, release date: 2023-11-08)

• Primary citation: Sridar, J.,Mafi, A.,Judge, R.A.,Xu, J.,Kong, K.A.,Wang, J.C.K.,Stoll, V.S.,Koukos, G.,Simon, R.J.,Eaton, D.,Bratkowski, M.,Hao, Q.; Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition; Commun Chem, 6:234-, 2023; DOI: 10.1038/s42004-023-01032-y

Experimental method

ELECTRON MICROSCOPY (3.13 Å)