8SL1
Cryo-EM structure of PAPP-A2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pappalysin-2 | polymer | 1570 | 174259.8 | 1 | UniProt (Q9BXP8) Pfam (PF13385) Pfam (PF00066) Pfam (PF05572) Pfam (PF25900) Pfam (PF00084) | Homo sapiens (human) | Pregnancy-associated plasma protein A2,PAPP-A2,Pregnancy-associated plasma protein E1,PAPP-E |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 1557 (UniProt: Q9BXP8)
| PDB | External Database | Details |
|---|---|---|
| Gln 500 | Glu 734 | conflict |
| Thr 1558 | - | expression tag |
| Arg 1559 | - | expression tag |
| Thr 1560 | - | expression tag |
| Gly 1561 | - | expression tag |
| Gly 1562 | - | expression tag |
| Asp 1563 | - | expression tag |
| Tyr 1564 | - | expression tag |
| Lys 1565 | - | expression tag |
| Asp 1566 | - | expression tag |
| Asp 1567 | - | expression tag |
| Asp 1568 | - | expression tag |
| Asp 1569 | - | expression tag |
| Lys 1570 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 174259.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 366.8 | |
| All* | Total formula weight | 175050.9 |
