6V06

Crystal structure of Beta-2 glycoprotein I purified from plasma (pB2GPI)

Summary for 6V06

• Entry DOI: 10.2210/pdb6v06/pdb
• Related: 1C1Z
• Descriptor: Beta-2-glycoprotein 1, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: plasma glycoprotein, coagulation, innate immune system, autoimmunity, thrombosis, sushi domain, blood clotting
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42608.11

Authors

Chen, Z.,Ruben, E.A.,Planer, W.,Chinnaraj, M.,Zuo, X.,Pengo, V.,Macor, P.,Tedesco, F.,Pozzi, N. (deposition date: 2019-11-18, release date: 2020-06-17, Last modification date: 2023-10-11)

• Primary citation: Ruben, E.,Planer, W.,Chinnaraj, M.,Chen, Z.,Zuo, X.,Pengo, V.,De Filippis, V.,Alluri, R.K.,McCrae, K.R.,Macor, P.,Tedesco, F.,Pozzi, N.; The J-elongated conformation of beta2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome.; J.Biol.Chem., 295:10794-10806, 2020; PubMed: 32518155; DOI: 10.1074/jbc.RA120.013939

Experimental method

X-RAY DIFFRACTION (2.4 Å)