Summary for 7PQN
Entry DOI | 10.2210/pdb7pqn/pdb |
Descriptor | Ecotin, Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, ... (5 entities in total) |
Functional Keywords | serine protease, complement, inhibitor, immune system |
Biological source | Escherichia coli (strain K12) More |
Total number of polymer chains | 6 |
Total formula weight | 108253.01 |
Authors | Harmat, V.,Fodor, K.,Heja, D. (deposition date: 2021-09-17, release date: 2022-05-18, Last modification date: 2024-01-31) |
Primary citation | Nagy, Z.A.,Heja, D.,Bencze, D.,Kiss, B.,Boros, E.,Szakacs, D.,Fodor, K.,Wilmanns, M.,Kocsis, A.,Dobo, J.,Gal, P.,Harmat, V.,Pal, G. Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. J.Biol.Chem., 298:101985-101985, 2022 Cited by PubMed: 35483450DOI: 10.1016/j.jbc.2022.101985 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.40001520992 Å) |
Structure validation
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