8GMN

Crystal structure of human C1s in complex with inhibitor

Summary for 8GMN

Entry DOI	10.2210/pdb8gmn/pdb
Descriptor	Complement C1s subcomponent, [4-(1-aminophthalazin-6-yl)piperazin-1-yl](2-methylphenyl)methanone, SULFATE ION, ... (4 entities in total)
Functional Keywords	complement c1s hydrolase. protease serine protease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	164674.72
Authors	Dougan, D.R.,Lane, W. (deposition date: 2023-03-26, release date: 2023-05-17, Last modification date: 2023-05-24)
Primary citation	Ikeda, Z.,Kamei, T.,Sasaki, Y.,Reynolds, M.,Sakai, N.,Yoshikawa, M.,Tawada, M.,Morishita, N.,Dougan, D.R.,Chen, C.H.,Levin, I.,Zou, H.,Kuno, M.,Arimura, N.,Kikukawa, Y.,Kondo, M.,Tohyama, K.,Sato, K. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J.Med.Chem., 66:6354-6371, 2023 Cited by PubMed: 37120845 DOI: 10.1021/acs.jmedchem.3c00348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation