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8GMN

Crystal structure of human C1s in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
B0004252molecular_functionserine-type endopeptidase activity
B0006508biological_processproteolysis
C0004252molecular_functionserine-type endopeptidase activity
C0006508biological_processproteolysis
D0004252molecular_functionserine-type endopeptidase activity
D0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGAFA
ChainResidueDetails
AASP626-ALA637

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"10775260","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-11-19

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