8GMN
Crystal structure of human C1s in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Complement C1s subcomponent | polymer | 371 | 40773.2 | 4 | UniProt (P09871) Pfam (PF00084) Pfam (PF00089) In PDB | Homo sapiens (human) | C1 esterase,Complement component 1 subcomponent s |
2 | A, B, C, D | [4-(1-aminophthalazin-6-yl)piperazin-1-yl](2-methylphenyl)methanone | non-polymer | 347.4 | 4 | Chemie (ZWK) | |||
3 | B, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 358 - 688 (UniProt: P09871)
PDB | External Database | Details |
---|---|---|
Met 318 | - | initiating methionine |
Leu 319 | - | expression tag |
Leu 320 | - | expression tag |
Val 321 | - | expression tag |
Asn 322 | - | expression tag |
Gln 323 | - | expression tag |
Ser 324 | - | expression tag |
His 325 | - | expression tag |
Gln 326 | - | expression tag |
Gly 327 | - | expression tag |
Phe 328 | - | expression tag |
Asn 329 | - | expression tag |
Lys 330 | - | expression tag |
Glu 331 | - | expression tag |
His 332 | - | expression tag |
Thr 333 | - | expression tag |
Ser 334 | - | expression tag |
Lys 335 | - | expression tag |
Met 336 | - | expression tag |
Val 337 | - | expression tag |
Ser 338 | - | expression tag |
Ala 339 | - | expression tag |
Ile 340 | - | expression tag |
Val 341 | - | expression tag |
Leu 342 | - | expression tag |
Tyr 343 | - | expression tag |
Val 344 | - | expression tag |
Leu 345 | - | expression tag |
Leu 346 | - | expression tag |
Ala 347 | - | expression tag |
Ala 348 | - | expression tag |
Ala 349 | - | expression tag |
Ala 350 | - | expression tag |
His 351 | - | expression tag |
Ser 352 | - | expression tag |
Ala 353 | - | expression tag |
Phe 354 | - | expression tag |
Ala 355 | - | expression tag |
Asp 356 | - | expression tag |
Leu 357 | - | expression tag |
Ala 518 | Glu 518 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 163092.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1581.8 | |
All* | Total formula weight | 164674.7 |