1ZJK
| Crystal structure of the zymogen catalytic region of human MASP-2 | Descriptor: | Mannan-binding lectin serine protease 2 | Authors: | Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P. | Deposit date: | 2005-04-29 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations J.Biol.Chem., 280, 2005
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3GOV
| Crystal structure of the catalytic region of human MASP-1 | Descriptor: | GLYCEROL, MASP-1 | Authors: | Harmat, V, Dobo, J, Beinrohr, L, Sebestyen, E, Zavodszky, P, Gal, P. | Deposit date: | 2009-03-20 | Release date: | 2009-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J.Immunol., 183, 2009
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2QY0
| Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts | Descriptor: | Complement C1r subcomponent, GLYCEROL | Authors: | Kardos, J, Harmat, V, Pallo, A, Barabas, O, Szilagyi, K, Graf, L, Naray-Szabo, G, Goto, Y, Zavodszky, P, Gal, P. | Deposit date: | 2007-08-13 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Mol.Immunol., 45, 2008
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2OAY
| Crystal structure of latent human C1-inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Plasma protease C1 inhibitor | Authors: | Harmat, V, Beinrohr, L, Gal, P, Dobo, J. | Deposit date: | 2006-12-18 | Release date: | 2007-05-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease J.Biol.Chem., 282, 2007
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1Q3X
| Crystal structure of the catalytic region of human MASP-2 | Descriptor: | GLYCEROL, Mannan-binding lectin serine protease 2, SODIUM ION | Authors: | Harmat, V, Gal, P, Kardos, J, Szilagyi, K, Ambrus, G, Naray-Szabo, G, Zavodszky, P. | Deposit date: | 2003-08-01 | Release date: | 2004-08-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions J.Mol.Biol., 342, 2004
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3TVJ
| Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold | Descriptor: | Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, Protease inhibitor SGPI-2, ... | Authors: | Heja, D, Harmat, V, Dobo, J, Szasz, R, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G. | Deposit date: | 2011-09-20 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287, 2012
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4DJZ
| Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold | Descriptor: | Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2 | Authors: | Heja, D, Harmat, V, Fodor, K, Wilmanns, M, Dobo, J, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G. | Deposit date: | 2012-02-03 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287, 2012
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