1Q3X
Crystal structure of the catalytic region of human MASP-2
Summary for 1Q3X
Entry DOI | 10.2210/pdb1q3x/pdb |
Descriptor | Mannan-binding lectin serine protease 2, SODIUM ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | complement, serine protease, modular structure, hinge bending, autoactivation, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: O00187 |
Total number of polymer chains | 2 |
Total formula weight | 72203.26 |
Authors | Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Naray-Szabo, G.,Zavodszky, P. (deposition date: 2003-08-01, release date: 2004-08-03, Last modification date: 2023-08-16) |
Primary citation | Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Vegh, B.,Naray-Szabo, G.,Zavodsky, P. The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions J.Mol.Biol., 342:1533-1546, 2004 Cited by PubMed: 15364579DOI: 10.1016/j.jmb.2004.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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