1Q3X

Crystal structure of the catalytic region of human MASP-2

Summary for 1Q3X

• Entry DOI: 10.2210/pdb1q3x/pdb
• Descriptor: Mannan-binding lectin serine protease 2, SODIUM ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: complement, serine protease, modular structure, hinge bending, autoactivation, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: O00187
• Total number of polymer chains: 2
• Total formula weight: 72203.26

Authors

Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Naray-Szabo, G.,Zavodszky, P. (deposition date: 2003-08-01, release date: 2004-08-03, Last modification date: 2023-08-16)

• Primary citation: Harmat, V.,Gal, P.,Kardos, J.,Szilagyi, K.,Ambrus, G.,Vegh, B.,Naray-Szabo, G.,Zavodsky, P.; The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions; J.Mol.Biol., 342:1533-1546, 2004; PubMed: 15364579; DOI: 10.1016/j.jmb.2004.07.014

Experimental method

X-RAY DIFFRACTION (2.23 Å)