4DJZ
Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold
Summary for 4DJZ
Entry DOI | 10.2210/pdb4djz/pdb |
Related | 3TVJ |
Descriptor | Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2, ... (4 entities in total) |
Functional Keywords | in vitro evolution, specific inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P48740 P48740 O46162 |
Total number of polymer chains | 6 |
Total formula weight | 99251.53 |
Authors | Heja, D.,Harmat, V.,Fodor, K.,Wilmanns, M.,Dobo, J.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G. (deposition date: 2012-02-03, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Heja, D.,Harmat, V.,Fodor, K.,Wilmanns, M.,Dobo, J.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G. Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287:20290-20300, 2012 Cited by PubMed: 22511776DOI: 10.1074/jbc.M112.354332 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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