4DJZ

Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold

Summary for 4DJZ

Entry DOI	10.2210/pdb4djz/pdb
Related	3TVJ
Descriptor	Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2, ... (4 entities in total)
Functional Keywords	in vitro evolution, specific inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P48740 P48740 O46162
Total number of polymer chains	6
Total formula weight	99251.53
Authors	Heja, D.,Harmat, V.,Fodor, K.,Wilmanns, M.,Dobo, J.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G. (deposition date: 2012-02-03, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Heja, D.,Harmat, V.,Fodor, K.,Wilmanns, M.,Dobo, J.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G. Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2. J.Biol.Chem., 287:20290-20300, 2012 Cited by PubMed: 22511776 DOI: 10.1074/jbc.M112.354332 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation