3TVJ

Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold

Summary for 3TVJ

• Entry DOI: 10.2210/pdb3tvj/pdb
• Related: 4DJZ
• Descriptor: Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, Protease inhibitor SGPI-2, ... (5 entities in total)
• Functional Keywords: in vitro evolution, specific inhibitor, allostery, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: O00187 O00187 O46162
• Total number of polymer chains: 3
• Total formula weight: 39876.91

Authors

Heja, D.,Harmat, V.,Dobo, J.,Szasz, R.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G. (deposition date: 2011-09-20, release date: 2012-04-25, Last modification date: 2023-09-13)

• Primary citation: Heja, D.,Harmat, V.,Fodor, K.,Wilmanns, M.,Dobo, J.,Kekesi, K.A.,Zavodszky, P.,Gal, P.,Pal, G.; Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.; J.Biol.Chem., 287:20290-20300, 2012; PubMed: 22511776; DOI: 10.1074/jbc.M112.354332

Experimental method

X-RAY DIFFRACTION (1.28 Å)