5UBM

Crystal structure of human C1s in complex with inhibitor gigastasin

Summary for 5UBM

Entry DOI	10.2210/pdb5ubm/pdb
Descriptor	Complement C1s subcomponent, Gigastasin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	complement system c1s protease inhibitor complex, immune system-inhibitor complex, immune system/inhibitor
Biological source	Haementeria ghilianii More
Total number of polymer chains	3
Total formula weight	61253.12
Authors	Pang, S.S.,Whisstock, J.C. (deposition date: 2016-12-20, release date: 2017-11-08, Last modification date: 2023-11-15)
Primary citation	Pang, S.S.,Wijeyewickrema, L.C.,Hor, L.,Tan, S.,Lameignere, E.,Conway, E.M.,Blom, A.M.,Mohlin, F.C.,Liu, X.,Payne, R.J.,Whisstock, J.C.,Pike, R.N. The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech. J. Immunol., 199:3883-3891, 2017 Cited by PubMed: 29061764 DOI: 10.4049/jimmunol.1700158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation